Nueva Publicación de nuestros investigadores

Gabriel Carrasco Escobar, Oscar NolascoDionicia GamboaAlejandro Llanos-Cuentas y Joseph M Vinetz   

Revista: Scientific Reports SJR: 1.01 Q: 1

Effect of out-of-village working activities on recent malaria exposure in the Peruvian Amazon using parametric g-formula

Gabriel Carrasco-Escobar 1 2Jason Rosado 3Oscar Nolasco 4 5Michael T White 3Ivo Mueller 6 7Marcia C Castro 8Hugo Rodriguez-Ferruci 9Dionicia Gamboa 4 5 10Alejandro Llanos-Cuentas 4Joseph M Vinetz 4 5 11Tarik Benmarhnia 12

Affiliations

  • 1Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA. Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo..
  • 2Health Innovation Lab, Institute of Tropical Medicine "Alexander Von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru. Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo..
  • 3G5 Épidémiologie Et Analyse Des Maladies Infectieuses, Département de Santé Globale, Institut Pasteur, 75015, Paris, France.
  • 4Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • 5Laboratorio ICEMR-Amazonia, Laboratorios de Investigación Y Desarrollo, Facultad de Ciencias Y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • 6Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
  • 7Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
  • 8Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • 9Universidad Nacional de La Amazonía Peruana, Loreto, Peru.
  • 10Departamento de Ciencias Celulares Y Moleculares, Facultad de Ciencias Y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • 11Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
  • 12Scripps Institution of Oceanography, University of California, San Diego, CA, 92037, USA.

PMID: 36351988

DOI: 10.1038/s41598-022-23528-8

Abstract

In the Amazon Region of Peru, occupational activities are important drivers of human mobility and may increase the individual risk of being infected while contributing to increasing malaria community-level transmission. Even though out-of-village working activities and other mobility patterns have been identified as determinants of malaria transmission, no studies have quantified the effect of out-of-village working activities on recent malaria exposure and proposed plausible intervention scenarios. Using two population-based cross-sectional studies in the Loreto Department in Peru, and the parametric g-formula method, we simulated various hypothetical scenarios intervening in out-of-village working activities to reflect their potential health benefits. This study estimated that the standardized mean outcome (malaria seroprevalence) in the unexposed population (no out-of-village workers) was 44.6% (95% CI: 41.7%-47.5%) and 66.7% (95% CI: 61.6%-71.8%) in the exposed population resulting in a risk difference of 22.1% (95% CI: 16.3%-27.9%). However, heterogeneous patterns in the effects of interest were observed between peri-urban and rural areas (Cochran's Q test = 15.5, p < 0.001). Heterogeneous patterns were also observed in scenarios of increased prevalence of out-of-village working activities and restriction scenarios by gender (male vs. female) and age (18 and under vs. 19 and older) that inform possible occupational interventions targetting population subgroups. The findings of this study support the hypothesis that targeting out-of-village workers will considerably benefit current malaria elimination strategies in the Amazon Region. Particularly, males and adult populations that carried out out-of-village working activities in rural areas contribute the most to the malaria seropositivity (recent exposure to the parasite) in the Peruvian Amazon.

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